ImmaticsHiring

Principal Manager, Clinical Operations Lead

  • USD 165,000 to 180,000 per year
  • Remote, United States
  • Lead
  • Posted 10 days ago
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In one line

Lead US regional clinical trials for a biotech working on precision cancer immunotherapy, from start-up through execution. Fully remote.

About the role

Oversight of CROs, vendors and internal study teams so trials hit quality, compliance, timeline and budget targets across the clinical programmes.

At a glance

Pay
USD 165,000 to 180,000 per year
Remote scope
Remote, United States
Seniority
Lead
Skills
Clinical operations, Clinical trial oversight, Vendor management, Oncology
Posted
19 Oct 2026
Last checked
27 Oct 2026

What you will do

  • Lead trial execution across internal teams and external partners from start-up onward
  • Oversee CROs and vendors against quality, compliance, timeline and budget goals
  • Head the CTM, CRA and CTA team on each assigned study and drive risk mitigation

What they look for

  • Bachelor's in life science, nursing or similar, plus 7 or more years leading global clinical operations
  • Experience in pharma or biotech, with strong analytical and problem-solving skills

Nice to have

  • Master's degree in a life science or nursing
  • Late phase or launch experience in oncology
  • Cell or gene therapy or other complex biologic programmes

Benefits

  • Health, dental and vision insurance at competitive rates
  • Four weeks of vacation granted up front each year
  • Twelve paid holidays and seven sick days

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Questions about this job

Is this job fully remote, and from where?

Yes. The posting lists Principal Manager, Clinical Operations Lead as a remote role for candidates in the United States.

What does this job pay?

The posting states USD 165,000 to 180,000 per year.

What experience is needed?

It is a lead role. The posting asks for: bachelor's in life science, nursing or similar, plus 7 or more years leading global clinical operations; experience in pharma or biotech, with strong analytical and problem-solving skills. Skills it names include Clinical operations, Clinical trial oversight, Vendor management, Oncology.

How do I apply with Keywordise AI?

Select Apply with Keywordise AI, sign up and upload your CV. Keywordise writes a CV and a cover letter for this job from your real experience and applies for you. The 7-day free trial needs no card.

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